Description
Identifies genetic predisposition to gluten intolerance by testing for the presence of the HLA DQ2 haplotype (DQA1*0501 and DQB1*0201 alleles) and HLA DQ8 allele (DQB1*0302).
Methodology
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When should I use
To identify genetic predisposition to gluten intolerance.
Coeliac disease is an autoimmune, inflammatory enteropathy triggered by the consumption of gluten-containing foods (including wheat, barley, rye, spelt) in genetically predisposed individuals (HLA-DQ2 / DQ8 positive). The result is a chronic inflammation of the small intestinal mucosa, as well as villus atrophy and malabsorption. The triggers are gliadin peptides from gluten, which pass through the small intestinal mucosa and are deamidated by tissue transglutaminase.
Other Details
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